بررسی تأثیر طولانی مدت فعالیت منظم ورزشی بر تغییرات پروفایل چربی و sVCAM-1 , sICAM-1 در زنان چاق

    Background & Aims : Based on research evidence prevalence of cardiovascular disease has inflammatory background and general inflammation (systemic) plays an important role in atherosclerosis progressing. These factors may increase the risk of such diseases particularly in overweight and obese men. The purpose of this study was to investigate long-term effects of regular exercise on lipid profile changes and sVCAM-1, sICAM-1 accumulation in obese women.   Materials & Methods : 36 healthy women participated in this study and randomly assigned to both exercise ( and 18 patients with an average age of 32± 41/2 years, BMI 34 ± 48/1 (kg/m2)) and control groups (n = 18 mean age, 32 ± 23/1 years, BMI 34/06 ± 24/03 (kg/m2)) respectively . Exercise program involved a 12-week training with intensity of 65-75% of maximum heart rate done three days per week in one session of 55-60 minute period. Serum levels of sVCAM-1, sICAM-1 evaluated by enzymatic Immunosorbent (Aymvnvzvrbnt) method using ELISA kits of BMS232 companies and BMS232TEN from Netherland. Also hs-CRP evaluated by immunoturbidometry method. Lipid profiles includes: low-density lipoprotein (LDL-C), high density lipoprotein (HDL-C), total cholesterol and triglycerides evaluetad by photometry and anthropometric indices and body composition were measured in pre and prostrating times. Data analysis was done on P<0.05 using SPSS.   Results : According to our findings after 12 weeks of training, there was significant differences in levels of sICAM-1andsVCAM-1, hs-CRP, TG, TC, LDL-c, HDL-c, LDL / HDL, TC / HDL between experiment and control groups. Also WHR, BMI and body fat percent was significantly reduced in the experimental group.   Conclusion : Regular exercise with reducing of inflammatory markers such as: sICAM-1, sVCAM-1, LDL-c, TG, TC may have a role in prevention and controlling of cardiovascular diseases . Also according to this fact that sICAM-1, sVCAM-1 are more sensitive indices than other lipid profiles, accurate measurement of those appears reasonable for detecting risk factors of heart disease.   SOURCE: URMIA MED J 2013: 24(7): 508 ISSN: 1027-3727